JT002, a small molecule inhibitor of the NLRP3 inflammasome for the treatment of autoinflammatory disorders
Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis
A Living Organoid Biobank of Crohn’s Disease Patients Reveals Molecular Subtypes for Personalized Therapeutics
Overcoming Preclinical Safety Obstacles to Discover (S)-N-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor
Artificial intelligence guided discovery of a barrier-protective therapy in inflammatory bowel disease
E-cigarettes compromise the gut barrier and trigger inflammation
The interaction of enteric bacterial effectors with the host engulfment pathway control innate immune responses
TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin
ELMO1 Regulates Autophagy Induction and Bacterial Clearance During Enteric Infection